{"id":6402,"date":"2016-01-16T18:23:35","date_gmt":"2016-01-16T17:23:35","guid":{"rendered":"http:\/\/histoweb.com\/en\/?p=6402"},"modified":"2022-11-14T18:55:38","modified_gmt":"2022-11-14T17:55:38","slug":"the-worm-turns","status":"publish","type":"post","link":"https:\/\/histoweb.com\/en\/the-worm-turns\/","title":{"rendered":"The worm turns"},"content":{"rendered":"<p>Coinfection in mice with <em>Schistosoma manson<\/em>i reduces mortality induced by <em>Toxocari canis<\/em> and prevents <em>Plasmodium<\/em>-associated brain lesions and, on the contrary, promotes replication of <em>Leishmania<\/em> and enhances susceptibility to tuberculosis. Such interactions are diifuclt to appraise with the reductionist approach of \u201cKoch\u2019s postulates\u201d, that were coined to determine when a particular organism could be held responsible for a particular disease state. The outcome of infection with a given organism does not always equate to disease. Besides the genetic background, intersecting influences of coinfecting organisms (from symbiotic microflora to virulent pathogens) affect the outcome of infection. And, because of their effects orchestrating host immunoregulation and chronic infections, helmiths provide examples of the potential of co-infections to alter diagnosis, course and outcome of disease processes. This paper decribes how helminths infections immunoregulate imflammatory responses and autoimmune reactions, as well as how they modulate pathogenicity, course and outcome to concurrent infection with other pathogens.<\/p>\n<p><a href=\"http:\/\/vet.sagepub.com\/content\/51\/2\/385.full.pdf\">The Worm Turns: Trematodes Steering the Course of Co-infections.<\/a> Vet Pathol 2014 51:328-340<\/p>\n<p style=\"text-align: center;\">Archive<\/p>\n<p><a href=\"\/en\/web-journal\/\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-4197 size-medium\" src=\"https:\/\/histoweb.com\/wp-content\/uploads\/2014\/11\/logo-web-journal-300x62.jpg\" alt=\"logo web journal\" width=\"300\" height=\"62\" srcset=\"https:\/\/histoweb.com\/wp-content\/uploads\/2014\/11\/logo-web-journal-300x62.jpg 300w, https:\/\/histoweb.com\/wp-content\/uploads\/2014\/11\/logo-web-journal.jpg 600w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Coinfection in mice with Schistosoma mansoni reduces mortality induced by Toxocari canis and prevents Plasmodium-associated brain lesions and, on the contrary, promotes replication of Leishmania and enhances susceptibility to tuberculosis. Such interactions are diifuclt to appraise with the reductionist approach of \u201cKoch\u2019s postulates\u201d, that were coined to determine when a particular organism could be held [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":6420,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-6402","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-web-journal-en"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The worm turns - Histoweb<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/histoweb.com\/en\/the-worm-turns\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The worm turns - Histoweb\" \/>\n<meta property=\"og:description\" content=\"Coinfection in mice with Schistosoma mansoni reduces mortality induced by Toxocari canis and prevents Plasmodium-associated brain lesions and, on the contrary, promotes replication of Leishmania and enhances susceptibility to tuberculosis. Such interactions are diifuclt to appraise with the reductionist approach of \u201cKoch\u2019s postulates\u201d, that were coined to determine when a particular organism could be held [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/histoweb.com\/en\/the-worm-turns\/\" \/>\n<meta property=\"og:site_name\" content=\"Histoweb\" \/>\n<meta property=\"article:published_time\" content=\"2016-01-16T17:23:35+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-11-14T17:55:38+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/histoweb.com\/wp-content\/uploads\/2016\/01\/Robert_Koch_BeW2.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"225\" \/>\n\t<meta property=\"og:image:height\" content=\"225\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Histovet\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Histovet\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/histoweb.com\/en\/the-worm-turns\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/histoweb.com\/en\/the-worm-turns\/\"},\"author\":{\"name\":\"Histovet\",\"@id\":\"https:\/\/histoweb.com\/#\/schema\/person\/d78fc7be2f2d4a1a7ddbe14459fec354\"},\"headline\":\"The worm turns\",\"datePublished\":\"2016-01-16T17:23:35+00:00\",\"dateModified\":\"2022-11-14T17:55:38+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/histoweb.com\/en\/the-worm-turns\/\"},\"wordCount\":169,\"publisher\":{\"@id\":\"https:\/\/histoweb.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/histoweb.com\/en\/the-worm-turns\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/histoweb.com\/wp-content\/uploads\/2016\/01\/Robert_Koch_BeW2.jpg\",\"articleSection\":[\"Articles\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/histoweb.com\/en\/the-worm-turns\/\",\"url\":\"https:\/\/histoweb.com\/en\/the-worm-turns\/\",\"name\":\"The worm turns - 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