Melanoma

In humans, melanomas are one of the most frequent and aggressive neoplasms and, although the incidence of skin forms has variability depending on the geographic area, uveal and mucocutaneous melanomas have a homogeneous morbidity. Both, in the case of skin melanomas related to UV radiation and in mucocutaneous tumors genetic abnormalities have been identified. Spontaneous melanomas in dogs are a model of their counterparts in the human species based on their inter-individual and intratumoral heterogeneity, metastasis, relapses and resistance to treatment. In this review work, authors carry out a comparative study of cutaneous and mucocutaneous melanomas in humans and dogs, reviewing clinical manifestations, genetic bases and different therapeutic alternatives.

Naturally Occurring Canine Melanoma as a Predictive Comparative Oncology Model for Human Mucosal and Other Triple Wild-Type Melanomas. Int J Mol Sci. 2018 Jan 30;19(2).

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