In humans, melanomas are one of the most frequent and aggressive neoplasms and, although the incidence of skin forms has variability depending on the geographic area, uveal and mucocutaneous melanomas have a homogeneous morbidity. Both, in the case of skin melanomas related to UV radiation and in mucocutaneous tumors genetic abnormalities have been identified. Spontaneous melanomas in dogs are a model of their counterparts in the human species based on their inter-individual and intratumoral heterogeneity, metastasis, relapses and resistance to treatment. In this review work, authors carry out a comparative study of cutaneous and mucocutaneous melanomas in humans and dogs, reviewing clinical manifestations, genetic bases and different therapeutic alternatives.

Naturally Occurring Canine Melanoma as a Predictive Comparative Oncology Model for Human Mucosal and Other Triple Wild-Type Melanomas. Int J Mol Sci. 2018 Jan 30;19(2).


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